AustralieFrV1, Main, Exploration, bibRecord, 003532

Role of miR-155 in the regulation of lymphocyte immune function and disease

Identifieur interne : 003532 ( Main/Exploration ); précédent : 003531; suivant : 003533

Role of miR-155 in the regulation of lymphocyte immune function and disease

Auteurs : Nabila Seddiki [France] ; Vedran Brezar [France] ; Nicolas Ruffin [France] ; Yves Lévy [France] ; Sanjay Swaminathan [Australie]

Source :

Immunology [ 0019-2805 ] ; 2014.

RBID : PMC:3992045

Abstract

MicroRNAs (miRNAs) have emerged as critical regulators of gene expression within cells. One particular miRNA, miR-155, is highly expressed within lymphocytes (both B and T cells) and mediates a number of important roles. These include shaping the transcriptome of lymphoid cells that control diverse biological functions vital in adaptive immunity. The use of mice engineered to be deficient in miR-155, as well as the identification of endogenous targets of miR-155 in T cells by transcriptome-wide analysis, has helped to unravel the crucial role that this miRNA plays in fine tuning the regulation of lymphocyte subsets such as B cells, CD8⁺ and CD4⁺ T cells ranging from T helper type 1 (Th1), Th2, Th17 and regulatory T cells. In this review, we summarize what we have learned about miR-155 in the regulation of lymphocyte responses at the cellular and molecular levels and in particular, we focus on the recent findings showing that miR-155 shapes the balance between tolerance and immunity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992045

DOI: 10.1111/imm.12227
PubMed: 24303979
PubMed Central: 3992045

Affiliations:

Australie, France

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>MicroRNAs (miRNAs) have emerged as critical regulators of gene expression within cells. One particular miRNA, miR-155, is highly expressed within lymphocytes (both B and T cells) and mediates a number of important roles. These include shaping the transcriptome of lymphoid cells that control diverse biological functions vital in adaptive immunity. The use of mice engineered to be deficient in miR-155, as well as the identification of endogenous targets of miR-155 in T cells by transcriptome-wide analysis, has helped to unravel the crucial role that this miRNA plays in fine tuning the regulation of lymphocyte subsets such as B cells, CD8<sup>+</sup>
 and CD4<sup>+</sup>
 T cells ranging from T helper type 1 (Th1), Th2, Th17 and regulatory T cells. In this review, we summarize what we have learned about miR-155 in the regulation of lymphocyte responses at the cellular and molecular levels and in particular, we focus on the recent findings showing that miR-155 shapes the balance between tolerance and immunity.</p>
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Serveur d'exploration sur les relations entre la France et l'Australie

Role of miR-155 in the regulation of lymphocyte immune function and disease

Role of miR-155 in the regulation of lymphocyte immune function and disease

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Abstract

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